منابع مشابه
Epigenetics meets endocrinology.
Although genetics determines endocrine phenotypes, it cannot fully explain the great variability and reversibility of the system in response to environmental changes. Evidence now suggests that epigenetics, i.e. heritable but reversible changes in gene function without changes in nucleotide sequence, links genetics and environment in shaping endocrine function. Epigenetic mechanisms, including ...
متن کاملVirus meets RNAi
Introduction Small rnas are important regulators of gene expression that operate through a range of rna-silencing mechanisms. of these, rna interference (rnai)—gene silencing through small-interfering rnas (sirnas) derived from exogenous double-stranded rna (dsrna)—and the microrna (mirna) pathway—gene silencing guided by small rnas encoded in the genome—are the best known. the discovery that d...
متن کاملRNAi and heterochromatin repress centromeric meiotic recombination.
During meiosis, the formation of viable haploid gametes from diploid precursors requires that each homologous chromosome pair be properly segregated to produce an exact haploid set of chromosomes. Genetic recombination, which provides a physical connection between homologous chromosomes, is essential in most species for proper homologue segregation. Nevertheless, recombination is repressed spec...
متن کاملRNAi - Mediated Targeting of Heterochromatin by
www.sciencemag.org (this information is current as of June 2, 2008 ): The following resources related to this article are available online at http://www.sciencemag.org/cgi/content/full/303/5658/672 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/1093686/DC1 can be found at: Sup...
متن کاملArabidopsis epigenetics: when RNA meets chromatin.
Recent work in plants and other eukaryotes has uncovered a major role for RNA interference in silent chromatin formation. The heritability of the silent state through multiple cell division cycles and, in some instances, through meiosis is assured by epigenetic marks. In plants, transposable elements and transgenes provide striking examples of the stable inheritance of repressed states, and are...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell Research
سال: 2009
ISSN: 1001-0602,1748-7838
DOI: 10.1038/cr.2009.13